The Cathedral of San Ciriaco stands as the most representative icon of the city of Ancona. This magnificent basilica, in Romanesque-Gothic style with Byzantine influences, stands on the ancient foundations of an Italic temple dating back to the 4th century B.C. and a later early Christian church.

Among the sights of interest are several not-to-be-missed sites: the Church of Santa Maria della Piazza, a masterpiece of Romanesque art with its façade adorned with small arches and symbolic sculptures around the portal; the Arch of Trajan, an imposing structure erected in the 1st century AD. ; the Church of San Francesco alle Scale, characterised by its elegant façade in Venetian Gothic style; the Mole Vanvitelliana, a splendid artificial island with a pentagonal profile within the port, designed by the papal architect Luigi Vanvitelli; the Loggia dei Mercanti, an important civil building in Venetian Gothic style; the suggestive Fontana del Calamo, also known as the Fontana delle Tredici Cannelle, whose name recalls its ancient Greek origins and the marshy environment in which it once stood.

Also not to be missed are the Pinacoteca Comunale, which houses a valuable collection of works of art including masterpieces by Carlo Crivelli, Titian, Lorenzo Lotto and Guercino; the Museo Archeologico Nazionale delle Marche, which recounts the prehistoric and protohistoric history of the Marche region; the Omero Tactile Museum, a unique experience that allows even the most.